After you’ve done what you can do, you need to help your mind disengage from her life to focus on your own

Let’s rephrase your question from, “Is there something wrong with me?” to, “How can I help myself deal more comfortably with such an uncomfortable, painful situation? It seems that your main problem is that you’re suffering physically and emotionally from a frightening situation that you can’t control. You want your sister to make better choices, you’ve tried to help her do that, you’ve failed to make an impact, and now you’re stuck watching what seems to be an inevitable train crash. You’re worrying to the point that your sleep and mood are affected.
By the way, your family members may or may not be similarly worried — parents especially may intentionally keep their concerns to themselves so as not to cause further distress within the family.
For some people, worrying about loved ones is a way of life. They show their love by worrying, believing it’s an expression of deep caring. It would be far better for them, however, if they could show their caring through prayer and positivity. Worry affects the body and mind negatively (something you’ve personally experienced), whereas connecting to Hashem and fostering faith has a powerfully healing effect on human beings.
Moreover, there’s a concept that worry is a form of negative prayer as it generates images of things going badly. “What if this bad thing happens or what if that bad thing happens?” To ask these questions, to allow oneself to wonder — or worse, obsess — about the possible disastrous scenarios requires generating those scenarios in the imagination. This then generates real-time sadness and grief of the yet-to-occur problem.
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